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American Journal of Roentgenology, Vol 100, 468-476, Copyright © 1967 by American Roentgen Ray Society

A CLINICAL AND HEMODYNAMIC EVALUATION OF A NEW CONTRAST MEDIUM

ISOPAQUE 440 (SODIUM AND N-METHYLGLUCAMINE METRIZOATE)

VICTOR HURST M.D.1, JAMES CHEN M.D.1, and HENRY MCINTOSH M.D.1

1 From the Cardiovascular Laboratory, Department of Medicine and the Department of Radiology, Duke University Medical Center, Durham, North Carolina

Isopaque 440, a new contrast medium was evaluated during the course of cineangiocardiography in 110 patients. This compound is a mixture of 32 per cent methylglucamine and 47 per cent sodium salt of a tri-iodinated compound metrizoate.

If warmth was excluded, 35 per cent of the 110 patients experienced adverse reactions of one form or another. None were persistent or of serious importance. Hemodynamic responses to this new agent were those related primarily to its hypertonicity and were not significantly different from those noted with other contrast media or hypertonic solutions. Neither clinical nor hemodynamic responses were serious, however, and none prompted the omission of a second injection, if clinically indicated, nor premature termination of the study.

This compound has the particular advantage of being highly soluble in water, thus providing a concentration of 440 mg. of iodine per ml. with a low viscosity. The resulting roentgenographic density was excellent.

This contrast medium deserves further clinical trial and should be a useful adjunct to diagnostic roentgenography.


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Copyright © 1967 by the American Roentgen Ray Society.