POST-IRRADIATIONAL RECURRENT EPIDERMOID CARCINOMA OF THE UTERINE CERVIX

¹ Department of Radiotherapy, University of Southern California School of Medicine, Los Angeles, California (formerly at the Roswell Park Memorial Institute).
² Department of Radiotherapy, Roswell Park Memorial Institute, Buffalo, New York.

During 1920 to 1954 there were 1,165 patients judged to have had recurrent cancers within a 10 year period following radiologic treatment of 4,308 cases of squamous cell carcinoma of the uterine cervix.

Forty-seven per cent of recurrences was detected by year, 60 per cent by 1 year, 73 per cent by 2, and 100 per cent by 9 years of follow-up for recurrences after radiotherapy. Thirty-seven per cent were pure cervical recurrences, 10.3 per cent pure vaginal, 2.4 per cent pure cervical and vaginal, 24.7 per cent parametrial with or without central disease, 10.8 per cent distant with or without pelvic disease. In 14.3 per cent of cases the exact sites of recurrences were not determined.

Retreatment was administered by individualized methods of roentgen irradiation and/or radium application. Only 11 cases were subjected to radical surgery. The over-all 5 year survival was 15 per cent. However, the results varied from 0 to 88 per cent when the sites of recurrences, initial stages, previous radiation factors, and retreatment modalities were considered.

Details of symptoms and signs in order of their appearances, time of recurrence and results of retreatment are presented in relationship to site of recurrence, initial clinical stage and initial radiation treatment factors.

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