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A NEW CONTRAST MEDIUM FOR CHOLANGIO-CHOLECYSTOGRAPHY: MEGLUMINE IODOXAMATE

E. NICHOLAS SARGENT M.D.1, ANDRE SCHULMAN M.B., M.R.C.P., F.F.R.1, HARVEY I. MEYERS M.D.1, RICHARD B. GUTLER M.D.2, JOHN T. NICOLOFF M.D.2, and LOUIS T. DIFAZIO PH.D.3

1 Department of Radiology.
2 Department of Medicine.; Department of Radiology, University of Cape Town, South Africa.
3 Squibb Institute for Medical Research.

A preliminary study of 18 patients following a single bolus intravenous injection of 10 to 30 cc. of meglumine iodoxamate (Cholovue), a new contrast medium for cholangio-cholecystography, showed no significant adverse clinical or laboratory effects with 10 and 20 cc., and only transient, minor changes with 30 cc. Early and persistent visualization of the subsegmental and major bile ducts and the gallbladder was obtained. Good to excellent opacification was obtained in all cases with doses ranging between 0.11 cc./kg. (19.7 mg. iodine) to 0.59 cc./kg. (108 mg. iodine). Meglumine iodoxamate appears to be a highly effective agent for cholangio-cholecystography.


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