Lymphoid follicular pattern: a normal feature of the pediatric colon

Tiny nodular filling defects up to 2 mm in diameter were seen in 12 of 27 patients under the age of 15 years undergoing double contrast enema. The pattern was particularly common in children under 5 years in whom a good quality double contrast study was obtained. While this pattern has been termed lymphoid hyperplasia, we believe it represents a normal lymphoid follicular pattern in the pediatric colon. The term lymphoid hyperplasia should be reserved for cases in which the lymphoid follicles are greater than 2 mm in diameter; this will usually represent an abnormal condition in response to infection, allergy, or immunologic disorders. The differential diagnosis of the lymphoid follicular pattern and lymphoid hyperplasia is briefly discussed.
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				E. Shteyer, B. Z. Koplewitz, E. Gross, and E. Granot Medical Treatment of Recurrent Intussusception Associated With Intestinal Lymphoid Hyperplasia Pediatrics, March 1, 2003; 111(3): 682 - 685. [Abstract] [Full Text] [PDF]