Progressive systemic sclerosis subgroups: variable pulmonary features

Evidence has accumulated which enables subdivision of progressive systemic sclerosis (scleroderma) into three categories: (1) classic progressive systemic sclerosis (PSS); (2) the CRST/CREST syndrome; or (3) overlap syndromes. Previous reports of the chest film manifestations of PSS have used only the broad category of scleroderma without subdivision. This study analyzed the chest film manifestations of 73 PSS patients which have been subgrouped. Radiographic abnormalities, either interstitial lung disease or pleural effusion, were present as follows: PSS, 18% (8/44); CRST/CREST, 0% (0/9); and PSS-overlap, 75% (15/20). Interstitial lung diseases in the PSS-overlap group was usually basilar and of mild severity on the initial chest film obtained. While the classic PSS group had a very much lower incidence of lung disease, it was usually more diffuse and severe.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A G Rockall, D Rickards, and P J Shaw Imaging of the pulmonary manifestations of systemic disease Postgrad. Med. J., October 1, 2001; 77(912): 621 - 638. [Full Text] [PDF]

				M Funauchi, S Ikoma, H Yu, M Sugiyama, M Ohno, K Kinoshita, K Hamada, and A Kanamaru A case of progressive systemic sclerosis complicated by massive pleural effusion with elevated CA125 Lupus, June 1, 2000; 9(5): 382 - 385. [Abstract] [PDF]

				R. J. Anderson and K. K. Hansen Case 44-1994- A 38-Year-Old Women with Chronic Rheumatoid Arthritis and a New Pleural Effusion N. Engl. J. Med., December 15, 1994; 331(24): 1642 - 1648. [Full Text]