AJR AJR Integrative Imaging Dec 2008 articles
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American Journal of Roentgenology, Vol 170, 649-652, Copyright © 1998 by American Roentgen Ray Society

ARTICLES

Pancreatic enhancement and pulse sequence analysis using low-dose mangafodipir trisodium

WW Mayo-Smith, W Schima, S Saini, GJ Slater and EG McFarland
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

OBJECTIVE: The purpose of this study was to evaluate pancreatic enhancement with low-dose mangafodipir trisodium (5 mumol/kg) using three different T1-weighted pulse sequences. SUBJECTS AND METHODS: Fifteen patients, six of whom had proven focal pancreatic tumors, underwent T1-weighted gradient-recalled echo imaging, spin-echo imaging, and fat-suppressed spin-echo imaging before and 30 min after injection of 5 mumol/kg of mangafodipir trisodium. Region-of-interest measurements were obtained in the pancreas before and after contrast enhancement. Signal-to-noise ratios were calculated in all 15 patients. Contrast-to-noise ratios were calculated in the six patients with pancreatic tumors. RESULTS: The signal-to-noise ratios of the pancreas increased after injection of mangafodipir trisodium on all three T1- weighted pulse sequences (p < .001). Enhanced fat-suppressed sequences (29 +/- 7.7) and gradient-recalled echo sequences (29 +/- 9.6) had the highest signal-to-noise ratios. Contrast-to-noise ratios between normal pancreatic tissue and pancreatic tumor also increased after contrast administration (p < .05) and were highest on the fat-suppressed (-9.6 +/- 4.0) pulse sequence. CONCLUSION: Mangafodipir trisodium produced marked pancreatic enhancement at a dose of 5 mumol/kg for all three T1- weighted pulse sequences. The enhanced T1-weighted spin-echo fat- suppressed sequence showed the highest signal-to-noise and contrast-to- noise ratios.
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Copyright © 1998 by the American Roentgen Ray Society.