AJR AJR Reprints & E-prints Available. Order Today!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sugahara, T.
Right arrow Articles by Takahashi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sugahara, T.
Right arrow Articles by Takahashi, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

American Journal of Roentgenology, Vol 171, 1479-1486, Copyright © 1998 by American Roentgen Ray Society

ARTICLES

Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas

T Sugahara, Y Korogi, M Kochi, I Ikushima, T Hirai, T Okuda, Y Shigematsu, L Liang, Y Ge, Y Ushio and M Takahashi
Department of Radiology, Kumamoto University School of Medicine, Honjo, Japan.

OBJECTIVE: Our purpose was to evaluate the relationships between the ratio of maximum relative cerebral blood volume (rCBV) (rCBV ratio = rCBV[tumor]/rCBV[contralateral white matter]) and histologic and angiographic vascularities of gliomas using the gradient-echo echoplanar MR imaging technique. We also evaluated the usefulness of rCBV maps for grading gliomas. SUBJECTS AND METHODS: We examined 30 patients with histologically verified gliomas. Gliomas were classified as glioblastoma, anaplastic glioma with enhancement, anaplastic glioma without enhancement, and low-grade glioma. The maximum rCBV ratio of each glioma was compared with both histologic and angiographic vascularities, and the relationship between the maximum rCBV ratios and each type of glioma was established. RESULTS: The maximum rCBV ratios of the gliomas significantly correlated with both histologic and angiographic vascularities (p < .001). Mean values and SDs of maximum rCBV ratios of each type of tumor were 7.32+/-4.39 for glioblastomas, 5.84+/-1.82 for anaplastic gliomas with enhancement, 1.53+/-0.75 for anaplastic gliomas without enhancement, and 1.26+/-0.55 for low-grade gliomas. The maximum rCBV ratios of the glioblastomas were significantly higher than those of the anaplastic gliomas without enhancement (p = .002) and the low-grade gliomas (p < .001). The maximum rCBV ratios of the anaplastic gliomas with enhancement were higher than those of the anaplastic gliomas without enhancement and the low-grade gliomas, but the differences were not statistically significant (p = .08 and p = .03, respectively). CONCLUSION: The results of perfusion-sensitive MR imaging with gradient-echo echoplanar technique correlated with both histologic and angiographic vascularities.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
T. Hirai, R. Murakami, H. Nakamura, M. Kitajima, H. Fukuoka, A. Sasao, M. Akter, Y. Hayashida, R. Toya, N. Oya, et al.
Prognostic Value of Perfusion MR Imaging of High-Grade Astrocytomas: Long-Term Follow-Up Study
AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1505 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
G. B. Caseiras, J.S. Thornton, T. Yousry, C. Benton, J. Rees, A.D. Waldman, and H.R. Jager
Inclusion or Exclusion of Intratumoral Vessels in Relative Cerebral Blood Volume Characterization in Low-Grade Gliomas: Does It Make a Difference?
AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1140 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. E. Emblem, B. Nedregaard, T. Nome, P. Due-Tonnessen, J. K. Hald, D. Scheie, O. C. Borota, M. Cvancarova, and A. Bjornerud
Glioma Grading by Using Histogram Analysis of Blood Volume Heterogeneity from MR-derived Cerebral Blood Volume Maps
Radiology, June 1, 2008; 247(3): 808 - 817.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
N. Danchaivijitr, A. D. Waldman, D. J. Tozer, C. E. Benton, G. Brasil Caseiras, P. S. Tofts, J. H. Rees, and H. R. Jager
Low-Grade Gliomas: Do Changes in rCBV Measurements at Longitudinal Perfusion-weighted MR Imaging Predict Malignant Transformation?
Radiology, April 1, 2008; 247(1): 170 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
N. Sadeghi, N. D'Haene, C. Decaestecker, M. Levivier, T. Metens, C. Maris, D. Wikler, D. Baleriaux, I. Salmon, and S. Goldman
Apparent Diffusion Coefficient and Cerebral Blood Volume in Brain Gliomas: Relation to Tumor Cell Density and Tumor Microvessel Density Based on Stereotactic Biopsies
AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 476 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H. Lu, E. Pollack, R. Young, J.S. Babb, G. Johnson, D. Zagzag, R. Carson, J.H. Jensen, J.A. Helpern, and M. Law
Predicting Grade of Cerebral Glioma Using Vascular-Space Occupancy MR Imaging
AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 373 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H.S. Kim and S.Y. Kim
A Prospective Study on the Added Value of Pulsed Arterial Spin-Labeling and Apparent Diffusion Coefficients in the Grading of Gliomas
AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1693 - 1699.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Cha, J.M. Lupo, M.-H. Chen, K.R. Lamborn, M.W. McDermott, M.S. Berger, S.J. Nelson, and W.P. Dillon
Differentiation of Glioblastoma Multiforme and Single Brain Metastasis by Peak Height and Percentage of Signal Intensity Recovery Derived from Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging
AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1078 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Law, R. Young, J. Babb, E. Pollack, and G. Johnson
Histogram Analysis versus Region of Interest Analysis of Dynamic Susceptibility Contrast Perfusion MR Imaging Data in the Grading of Cerebral Gliomas
AJNR Am. J. Neuroradiol., April 1, 2007; 28(4): 761 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. C. Pereira, D. E. Huddleston, A. M. Brickman, A. A. Sosunov, R. Hen, G. M. McKhann, R. Sloan, F. H. Gage, T. R. Brown, and S. A. Small
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
PNAS, March 27, 2007; 104(13): 5638 - 5643.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
N. Sadeghi, I. Salmon, C. Decaestecker, M. Levivier, T. Metens, D. Wikler, V. Denolin, S. Rorive, N. Massager, D. Baleriaux, et al.
Stereotactic Comparison among Cerebral Blood Volume, Methionine Uptake, and Histopathology in Brain Glioma
AJNR Am. J. Neuroradiol., March 1, 2007; 28(3): 455 - 461.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Law, R. Young, J. Babb, M. Rad, T. Sasaki, D. Zagzag, and G. Johnson
Comparing Perfusion Metrics Obtained from a Single Compartment Versus Pharmacokinetic Modeling Methods Using Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade.
AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1975 - 1982.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. M. Provenzale, G. York, M. G. Moya, L. Parks, M. Choma, S. Kealey, P. Cole, and H. Serajuddin
Correlation of Relative Permeability and Relative Cerebral Blood Volume in High-Grade Cerebral Neoplasms
Am. J. Roentgenol., October 1, 2006; 187(4): 1036 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
V S Khoo and D L Joon
New developments in MRI for target volume delineation in radiotherapy
Br. J. Radiol., September 1, 2006; 79(Special_Issue_1): S2 - S15.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. A. Weber, S. Zoubaa, M. Schlieter, E. Juttler, H. B. Huttner, K. Geletneky, C. Ittrich, M. P. Lichy, A. Kroll, J. Debus, et al.
Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors
Neurology, June 27, 2006; 66(12): 1899 - 1906.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. M. Provenzale, S. Mukundan, and D. P. Barboriak
Diffusion-weighted and Perfusion MR Imaging for Brain Tumor Characterization and Assessment of Treatment Response.
Radiology, June 1, 2006; 239(3): 632 - 649.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S.J. Mills, T.A. Patankar, H.A. Haroon, D. Baleriaux, R. Swindell, and A. Jackson
Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma?
AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 853 - 858.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
Y. Cao, P. C. Sundgren, C. I. Tsien, T. T. Chenevert, and L. Junck
Physiologic and Metabolic Magnetic Resonance Imaging in Gliomas
J. Clin. Oncol., March 10, 2006; 24(8): 1228 - 1235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Cha
Update on Brain Tumor Imaging: From Anatomy to Physiology
AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 475 - 487.
[Full Text] [PDF]

Home page
 RadiologyHome page
M. Law, S. Oh, J. S. Babb, E. Wang, M. Inglese, D. Zagzag, E. A. Knopp, and G. Johnson
Low-Grade Gliomas: Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging--Prediction of Patient Clinical Response
Radiology, February 1, 2006; 238(2): 658 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T. F. Patankar, H. A. Haroon, S. J. Mills, D. Baleriaux, D. L. Buckley, G. J.M. Parker, and A. Jackson
Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas?
AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2455 - 2465.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
N. Bulakbasi, M. Kocaoglu, A. Farzaliyev, C. Tayfun, T. Ucoz, and I. Somuncu
Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors
AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2187 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
X. Li, D. B. Vigneron, S. Cha, E. E. Graves, F. Crawford, S. M. Chang, and S. J. Nelson
Relationship of MR-Derived Lactate, Mobile Lipids, and Relative Blood Volume for Gliomas in Vivo
AJNR Am. J. Neuroradiol., April 1, 2005; 26(4): 760 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. C. M. Maia Jr, S. M. F. Malheiros, A. J. da Rocha, C. J. da Silva, A. A. Gabbai, F. A. P. Ferraz, and J. N. Stavale
MR Cerebral Blood Volume Maps Correlated with Vascular Endothelial Growth Factor Expression and Tumor Grade in Nonenhancing Gliomas
AJNR Am. J. Neuroradiol., April 1, 2005; 26(4): 777 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Cha, T. Tihan, F. Crawford, N. J. Fischbein, S. Chang, A. Bollen, S. J. Nelson, M. Prados, M. S. Berger, and W. P. Dillon
Differentiation of Low-Grade Oligodendrogliomas from Low-Grade Astrocytomas by Using Quantitative Blood-Volume Measurements Derived from Dynamic Susceptibility Contrast-Enhanced MR Imaging
AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 266 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H. R. Jager, A. D Waldman, C. Benton, N. Fox, and J. Rees
Differential Chemosensitivity of Tumor Components in a Malignant Oligodendroglioma: Assessment with Diffusion-Weighted, Perfusion-Weighted, and Serial Volumetric MR Imaging
AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 274 - 278.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Law, K. Kazmi, S. Wetzel, E. Wang, C. Iacob, D. Zagzag, J. G. Golfinos, and G. Johnson
Dynamic Susceptibility Contrast-Enhanced Perfusion and Conventional MR Imaging Findings for Adult Patients with Cerebral Primitive Neuroectodermal Tumors
AJNR Am. J. Neuroradiol., June 1, 2004; 25(6): 997 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Law, A. M. Saindane, Y. Ge, J. S. Babb, G. Johnson, L. J. Mannon, J. Herbert, and R. I. Grossman
Microvascular Abnormality in Relapsing-Remitting Multiple Sclerosis: Perfusion MR Imaging Findings in Normal-appearing White Matter
Radiology, June 1, 2004; 231(3): 645 - 652.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Law, S. Yang, J. S. Babb, E. A. Knopp, J. G. Golfinos, D. Zagzag, and G. Johnson
Comparison of Cerebral Blood Volume and Vascular Permeability from Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade
AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 746 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. H. Lev, Y. Ozsunar, J. W. Henson, A. A. Rasheed, G. D. Barest, G. R. Harsh IV, M. M. Fitzek, E. A. Chiocca, J. D. Rabinov, A. N. Csavoy, et al.
Glial Tumor Grading and Outcome Prediction Using Dynamic Spin-Echo MR Susceptibility Mapping Compared with Conventional Contrast-Enhanced MR: Confounding Effect of Elevated rCBV of Oligodendroglimoas
AJNR Am. J. Neuroradiol., February 1, 2004; 25(2): 214 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
A R Padhani
MRI for assessing antivascular cancer treatments
Br. J. Radiol., December 1, 2003; 76(suppl_1): S60 - S80.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Law, S. Yang, H. Wang, J. S. Babb, G. Johnson, S. Cha, E. A. Knopp, and D. Zagzag
Glioma Grading: Sensitivity, Specificity, and Predictive Values of Perfusion MR Imaging and Proton MR Spectroscopic Imaging Compared with Conventional MR Imaging
AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 1989 - 1998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. G. Wetzel, S. Cha, M. Law, G. Johnson, J. Golfinos, P. Lee, and P. K. Nelson
Preoperative Assessment of Intracranial Tumors with Perfusion MR and a Volumetric Interpolated Examination: A Comparative Study with DSA
AJNR Am. J. Neuroradiol., November 1, 2002; 23(10): 1767 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
W.-C. Wu, C.-Y. Chen, H.-W. Chung, C.-J. Juan, C.-J. Hsueh, and H.-W. Gao
Discrepant MR Spectroscopic and Perfusion Imaging Results in a Case of Malignant Transformation of Cerebral Glioma
AJNR Am. J. Neuroradiol., November 1, 2002; 23(10): 1775 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. H. Shin, H. K. Lee, B. D. Kwun, J.-S. Kim, W. Kang, C. G. Choi, and D. C. Suh
Using Relative Cerebral Blood Flow and Volume to Evaluate the Histopathologic Grade of Cerebral Gliomas: Preliminary Results
Am. J. Roentgenol., September 1, 2002; 179(3): 783 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. A. Tzika, M. K. Zarifi, L. Goumnerova, L. G. Astrakas, D. Zurakowski, T. Young-Poussaint, D. C. Anthony, R. M. Scott, and P. McL. Black
Neuroimaging in Pediatric Brain Tumors: Gd-DTPA-enhanced, Hemodynamic, and Diffusion MR Imaging Compared with MR Spectroscopic Imaging
AJNR Am. J. Neuroradiol., February 1, 2002; 23(2): 322 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H. Uematsu, M. Maeda, N. Sadato, T. Matsuda, Y. Ishimori, Y. Koshimoto, H. Kimura, H. Yamada, Y. Kawamura, Y. Yonekura, et al.
Blood Volume of Gliomas Determined by Double-Echo Dynamic Perfusion-Weighted MR Imaging: A Preliminary Study
AJNR Am. J. Neuroradiol., November 1, 2001; 22(10): 1915 - 1919.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T. Sugahara, Y. Korogi, M. Kochi, Y. Ushio, and M. Takahashi
Perfusion-sensitive MR Imaging of Gliomas: Comparison between Gradient-echo and Spin-echo Echo-planar Imaging Techniques
AJNR Am. J. Neuroradiol., August 1, 2001; 22(7): 1306 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
R. Bruening, C. Berchtenbreiter, N. Holzknecht, M. Essig, R. H. Wu, A. Simmons, A. Heuck, A. Maschek, M. Meusel, S. C. R. Williams, et al.
Effects of Three Different Doses of a Bolus Injection of Gadodiamide: Assessment of Regional Cerebral Blood Volume Maps in a Blinded Reader Study
AJNR Am. J. Neuroradiol., October 1, 2000; 21(9): 1603 - 1610.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
H. C. Roberts, T. P. L. Roberts, R. C. Brasch, and W. P. Dillon
Quantitative Measurement of Microvascular Permeability in Human Brain Tumors Achieved Using Dynamic Contrast-enhanced MR Imaging: Correlation with Histologic Grade
AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 891 - 899.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
T. Sugahara, Y. Korogi, S. Tomiguchi, Y. Shigematsu, I. Ikushima, T. Kira, L. Liang, Y. Ushio, and M. Takahashi
Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue
AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 901 - 909.
[Abstract] [Full Text]

Home page
 RadiologyHome page
W. G. Bradley and R. B. Shey
MR Imaging Evaluation of Seizures
Radiology, March 1, 2000; 214(3): 651 - 656.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
L. Liang, Y. Korogi, T. Sugahara, Y. Shigematsu, T. Okuda, I. Ikushima, and M. Takahashi
Detection of Intracranial Hemorrhage with Susceptibility-Weighted MR Sequences
AJNR Am. J. Neuroradiol., September 1, 1999; 20(8): 1527 - 1534.
[Abstract] [Full Text]

Home page
 RadiologyHome page
M. Law, S. Cha, E. A. Knopp, G. Johnson, J. Arnett, and A. W. Litt
High-Grade Gliomas and Solitary Metastases: Differentiation by Using Perfusion and Proton Spectroscopic MR Imaging
Radiology, March 1, 2002; 222(3): 715 - 721.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Cha, E. A. Knopp, G. Johnson, S. G. Wetzel, A. W. Litt, and D. Zagzag
Intracranial Mass Lesions: Dynamic Contrast-enhanced Susceptibility-weighted Echo-planar Perfusion MR Imaging
Radiology, April 1, 2002; 223(1): 11 - 29.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Roentgen Ray Society.