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American Journal of Roentgenology, Vol 172, 1343-1346, Copyright © 1999 by American Roentgen Ray Society

ARTICLES

Platelet glycoprotein IIb/IIIa receptor antagonist used in conjunction with thrombolysis for peripheral arterial thrombosis

G Tepe, U Schott, CM Erley, J Albes, CD Claussen and SH Duda
Department of Diagnostic Radiology, Eberhard-Karls-Universitat Tubingen, Germany.

OBJECTIVE: This feasibility study was designed to evaluate the therapeutic potential of intraarterial urokinase combined with abciximab, an IV platelet glycoprotein IIb/IIIa receptor antagonist, in peripheral arterial thrombosis. CONCLUSION: The administration of a highly potent glycoprotein IIb/IIIa inhibitor in conjunction with intraarterial fibrinolysis was safe in 14 patients. One distal embolization and no major bleeding occurred. The primary success rate was 100%. Treatment times ranged from 50 min to 8 hr. We found a reocclusion rate of 7% (1/14) at intermediate follow-up.
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