AJR Get Involved! Join ARRS Today
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Albrecht, T.
Right arrow Articles by Wolf, K.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Albrecht, T.
Right arrow Articles by Wolf, K.-J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
AJR 2001; 176:1191-1198
© American Roentgen Ray Society

Phase-Inversion Sonography During the Liver-Specific Late Phase of Contrast Enhancement

Improved Detection of Liver Metastases

Thomas Albrecht1, Christian W. Hoffmann1, Stephan A. Schmitz1, Stefan Schettler1, Aline Overberg1, Christoph T. Germer2 and Karl-Jürgen Wolf1

1 Department of Radiology and Nuclear Medicine, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany.
2 Department of Surgery, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, D-12200 Berlin, Germany.

OBJECTIVE. The purpose of our study was to assess whether phase-inversion sonography during the late, liver-specific phase of contrast enhancement using Levovist improves the detection of hepatic metastases relative to unenhanced conventional B-mode sonography.

SUBJECTS AND METHODS. Sixty-two patients were studied with unenhanced B-mode sonography and phase-inversion sonography 2.5 min after the injection of Levovist. All patients underwent one reference examination (CT, MR imaging, or intraoperative sonography). The conspicuity, number, size, and distribution of metastases before and after contrast administration as judged by a sonographer (who was unaware of other imaging findings) were compared with each other and with reference imaging.

RESULTS. The conspicuity of metastases was improved by contrast-enhanced phase inversion in 94% of patients. Thirty-nine patients showed metastases on reference imaging; 36 of these were positive on baseline sonography and 38 on phase-inversion sonography. Phase-inversion sonography showed more reference imaging—confirmed metastases than baseline sonography in 28 patients (45%). The average number of confirmed metastases per patient was 3.06 for baseline sonography and 5.42 for contrast-enhanced phase-inversion sonography (p < 0.01). The average sensitivity for detecting individual metastases improved from 63% to 91%. Metastases of less than 1 cm were shown in 14 patients on baseline sonography, in 24 patients on phase-inversion sonography, and in 26 on reference imaging. Both sonographic techniques showed false-positive lesions in six patients.

CONCLUSION. Contrast-enhanced phase-inversion sonography in the liver-specific phase of contrast enhancement using Levovist provides a marked improvement in the detection of hepatic metastases relative to unenhanced conventional sonography, without loss of specificity. Phase-inversion sonography was particularly advantageous in detecting small metastases and may be a competitive alternative to CT and MR imaging.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Ultrasound MedHome page
O. Catalano, V. Migaleddu, E. Quaia, and G. Caruso
Terminology for Contrast-Enhanced Sonography: A Practical Glossary
J. Ultrasound Med., June 1, 2007; 26(6): 717 - 730.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
S. Gultekin, C. Yucel, H. Ozdemir, H. Celik, S. O. Oktar, and M. Arac
The role of late-phase pulse inversion harmonic imaging in the detection of occult hepatic metastases.
J. Ultrasound Med., September 1, 2006; 25(9): 1139 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. J. Dill-Macky, M. Asch, P. Burns, and S. Wilson
Radiofrequency ablation of hepatocellular carcinoma: predicting success using contrast-enhanced sonography.
Am. J. Roentgenol., May 1, 2006; 186(5 Suppl): S287 - S295.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
C. Nicolau, R. Vilana, V. Catala, L. Bianchi, R. Gilabert, A. Garcia, and C. Bru
Importance of Evaluating All Vascular Phases on Contrast-Enhanced Sonography in the Differentiation of Benign from Malignant Focal Liver Lesions
Am. J. Roentgenol., January 1, 2006; 186(1): 158 - 167.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Okada, C. W. Hoffmann, K. J. Wolf, and T. Albrecht
Bolus versus Continuous Infusion of Microbubble Contrast Agent for Liver US: Initial Experience
Radiology, December 1, 2005; 237(3): 1063 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
H. Celik, H. Ozdemir, C. Yucel, S. Gultekin, S. O. Oktar, and M. Arac
Characterization of Hyperechoic Focal Liver Lesions: Quantitative Evaluation With Pulse Inversion Harmonic Imaging in the Late Phase of Levovist
J. Ultrasound Med., January 1, 2005; 24(1): 39 - 47.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
A. von Herbay, C. Vogt, R. Willers, and D. Haussinger
Real-time Imaging With the Sonographic Contrast Agent SonoVue: Differentiation Between Benign and Malignant Hepatic Lesions
J. Ultrasound Med., December 1, 2004; 23(12): 1557 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
Y. L. Wen, M. Kudo, R. Q. Zheng, H. Ding, P. Zhou, Y. Minami, H. Chung, M. Kitano, T. Kawasaki, and K. Maekawa
Characterization of Hepatic Tumors: Value of Contrast-Enhanced Coded Phase-Inversion Harmonic Angio
Am. J. Roentgenol., April 1, 2004; 182(4): 1019 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C F Dietrich, A Ignee, J Trojan, C Fellbaum, and G Schuessler
Improved characterisation of histologically proven liver tumours by contrast enhanced ultrasonography during the portal venous and specific late phase of SHU 508A
Gut, March 1, 2004; 53(3): 401 - 405.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. Isozaki, K. Numata, T. Kiba, K. Hara, M. Morimoto, T. Sakaguchi, H. Sekihara, T. Kubota, H. Shimada, T. Morizane, et al.
Differential Diagnosis of Hepatic Tumors by Using Contrast Enhancement Patterns at US
Radiology, December 1, 2003; 229(3): 798 - 805.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. Albrecht, M. J. K. Blomley, P. N. Burns, S. Wilson, C. J. Harvey, E. Leen, M. Claudon, F. Calliada, J.-M. Correas, M. LaFortune, et al.
Improved Detection of Hepatic Metastases with Pulse-Inversion US during the Liver-specific Phase of SHU 508A: Multicenter Study
Radiology, May 1, 2003; 227(2): 361 - 370.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
K. Khalili, U. Metser, and S. R. Wilson
Hilar Biliary Obstruction: Preliminary Results with Levovist-Enhanced Sonography
Am. J. Roentgenol., March 1, 2003; 180(3): 687 - 693.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. von Herbay, C. Vogt, and D. Haussinger
Late-Phase Pulse-Inversion Sonography Using the Contrast Agent Levovist: Differentiation Between Benign and Malignant Focal Lesions of the Liver
Am. J. Roentgenol., November 1, 2002; 179(5): 1273 - 1279.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Roentgen Ray Society.