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1 Department of Diagnostic and Interventional Radiology, University Hospital
Essen, Hufelandstrasse 55, Essen 45122, Germany.
2 Department of Angiology, University Hospital Essen, Essen 45122,
Germany.
3 Department of Radiology, Catholic Hospitals Essen-Nord, Hospitalstrasse 24,
Essen 45329, Germany.
OBJECTIVE. We assessed the diagnostic performance of whole-body 3D contrast-enhanced MR angiography in comparison with digital subtraction angiography (DSA) of the lower extremities in patients with peripheral arterial occlusive disease.
SUBJECTS AND METHODS. Fifty-one patients with clinically documented peripheral arterial occlusive disease referred for DSA of the lower extremity arterial system underwent whole-body MR angiography on a 1.5-T MR scanner. Paramagnetic gadobutrol was administered and five contiguous stations were acquired with 3D T1-weighted gradient-echo sequences in a total scanning time of 72 sec. DSA was available as a reference standard for the peripheral vasculature in all patients. Separate blinded data analyses were performed by two radiologists. Additional vascular disease detected by whole-body MR angiography was subsequently assessed on sonography, dedicated MR angiography, or both.
RESULTS. All whole-body MR angiography examinations were feasible
and well tolerated. AngioSURF-based whole-body MR angiography had overall
sensitivities of 92.3% and 93.1% (both 95% confidence intervals [CIs],
78–100%) with specificities of 89.2% and 87.6% (both CIs, 84–98%)
and excellent interobserver agreement (
= 0.82) for the detection of
high-grade stenoses. Additional vascular disease was detected in 12 patients
(23%).
CONCLUSION. Whole-body MR angiography permits a rapid, noninvasive, and accurate evaluation of the lower peripheral arterial system in patients with peripheral arterial occlusive disease, and it may allow identification of additional relevant vascular disease that was previously undetected.
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