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Routine Use of Gradient-Echo MRI to Screen for Cerebral Amyloid Angiopathy in Elderly Patients

¹ Department of Radiology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224-1865.
² Department of Neurology, Mayo Clinic, Jacksonville, FL 32224-1865.

OBJECTIVE. The objective of this study was to evaluate the routine use of gradient-refocused echo MRI sequences in the detection of cortical cerebral microbleeding suggestive of cerebral amyloid angiopathy in elderly patients (> 70 years old).

CONCLUSION. The addition of gradient-refocused echo sequences to routine brain MRI resulted in the identification of cerebral amyloid angiopathy–related microbleeding in 15.5% of elderly patients. In most (86.7%) of these patients with positive findings, cerebral amyloid angiopathy was not suspected clinically, and 46.7% of these patients were undergoing anticoagulant or aspirin therapy, placing them at an increased risk of recurrent intracranial hemorrhage and catastrophic stroke.

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