HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Karaolanolu, M. Articles by Ziylan, S. Z. Search for Related Content PubMed PubMed Citation Articles by Karaolanolu, M. Articles by Ziylan, S. Z. Social Bookmarking                      What's this?

Effect of Different Pharmacologic and Chemical Agents on the Integrity of Hydatid Cyst Membranes

Mustafa Karaolanolu¹, Ömer Faruk Akinci², Sedat Bozkurt¹, eyhmus Deniz¹, Gülhiz Karata¹, Ali Cokun² and Salih Zeki Ziylan¹

¹ Radiology Department, Harran University Medical Faculty, anliurfa 63100, Turkey.
² General Surgery Department, Harran University Medical Faculty, anliurfa 63100, Turkey.

OBJECTIVE. We performed an in vitro investigation of the effects of widely used scolicidal and sclerosing agents, as well as some pharmacologic products, on the integrity of the membrane of hydatid cysts.

MATERIALS AND METHODS. Two milliliters each of 22 agents, 2 mL of clear fluid, and one piece of hydatid cyst membrane were put into bottles. The hydatid cyst membranes were evaluated by visual observation and manual palpation. Visual examination of the bottles was performed daily for 7 days, and observations of membrane changes, including translucency, destruction, swelling, and melting, were recorded. Manual evaluation was done on the seventh day by finger examination, and membrane fragility was scored.

RESULTS. The hydatid cyst membrane was completely melted in a few minutes in a 2.5% solution of sodium hypochlorite and in 1 hr by a 0.1% sodium hypochlorite solution. The integrity of the hydatid cyst membrane was preserved in alcohol, acetone, glutaraldehyde, albendazole, acetylsalicylic acid, formaldehyde, lidocaine, hydrochloric acid, ammonia, pancreatin, Betadine, methylene blue, and isotonic saline samples. The membranes in the metronidazole and hypertonic saline solutions were not damaged but showed significantly increased fragility. The membranes in levamisole and piperazine hexahydrate became translucent and showed moderate fragility.

CONCLUSION. None of the agents that are used in clinical practice had important effects on the dissolution of hydatid cyst membranes. However, sodium hypochlorite solutions completely melted the hydatid cyst membranes. Because the use of this agent on living tissue is limited, further study is needed to investigate its clinical use.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Brunetti, R. Gulizia, G. Troia, C. Filice, M. Karaoglanoglu, and O. F. Akinci Effects of Chemical Agents on Hydatid Cyst Membranes Am. J. Roentgenol., March 1, 2005; 184(3): 1025 - 1026. [Full Text] [PDF]