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American Journal of Roentgenology, Vol 97, 755-761, Copyright © 1966 by American Roentgen Ray Society

EXPERIMENTAL EVALUATION OF CONCENTRATED SOLUTIONS OF IOTHALAMIC ACID DERIVATIVES AS ANGIOGRAPHIC CONTRAST MEDIA

CAULEY W. HAYES M.D.1, JOHN H. FOSTER M.D.1, ROBERT SEWELL B.S.1, and DUNCAN A. KILLEN M.D.1

1 From the S.R. Light Laboratory for Surgical Research, The Surgical Research Laboratory, Veterans Administration Hospital, and the Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee

Two new concentrated contrast agents, MP 1005.2 and MP 2032, which are derivatives of iothalamic acid have been tested as angiographic contrast media. The results have been compared to results obtained with hypaque M-90; both of the new media proved to be less neurotoxic and nephrotoxic. Thus, in equivalent solutions iothalamate salts proved to be less toxic than the diatrizoate salts. The intravenous tolerance of these media was far better than with hypaque M-90. MP 2032 is far too viscous for use as a concentrated medium—it may find usefulness as a less concentrated contrast agent. MP 1005.2 is sufficiently impressive to warrant trial as an aortographic medium—especially in thoracic aortography.


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T.R. Marshall
Clinical Evaluation of Vascoray (Sodium Iothalamate 26%/Methylglucamine Iothalamate 52%) a New Contrast Medium
Angiology, May 1, 1973; 24(5): 288 - 296.
[Abstract] [PDF]


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Copyright © 1966 by the American Roentgen Ray Society.