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Angiofollicular Lymphoid Hyperplasia (Castleman Disease) of the Axilla

Liem T. Bui-Mansfield1, Felix S. Chew1 and Cris P. Myers2

1 Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1088
2 Department of Pathology, Walter Reed Army Medical Center, 6900 Georgia Ave. N. W., Washington, DC 20307.



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  		Fig. 1A. —37-year-old woman with angiofollicular lymphoid hyperplasia of axilla. Sonogram of axilla shows ovoid hypoechoic mass containing hypoechoic tubular structures.

 


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  		Fig. 1B. —37-year-old woman with angiofollicular lymphoid hyperplasia of axilla. Color Doppler sonogram shows vascular flow within mass.

 


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  		Fig. 1C. —37-year-old woman with angiofollicular lymphoid hyperplasia of axilla. Photomicrograph of histopathologic specimen shows lymphoid follicles surrounded by stroma that contain numerous hyperplastic capillaries, venules, and arterioles. (H and E, low power)

 


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  		Fig. 1D. —37-year-old woman with angiofollicular lymphoid hyperplasia of axilla. Photomicrograph of histopathologic specimen shows concentric layering of follicular lymphocytes around hyalinized central vessel producing characteristic "onion skin" pattern. (H and E, high power)

 

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