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Unusual Patterns of Hepatic Steatosis Caused by the Local Effect of Insulin Revealed on Chemical Shift MR Imaging

Jane Sohn1, Evan S. Siegelman1 and Andrew W. Osiason2

1 Department of Radiology, University of Pennsylvania Medical School, First Floor Silverstein, 3400 Spruce St., Philadelphia, PA 19104-4283.
2 Department of Radiology, Hackensack University Medical Center, 30 Prospect St., Hackensack, NJ 07601.



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Fig. 1A. Focal rim of hepatic steatosis surrounding an insulinoma metastasis in 27-year-old man. Axial breath-hold spoiled in-phase gradient-echo image (TR/TE, 250/4.2) shows 12-mm liver mass (straight arrow). Note phase-encoding artifact from aorta (curved arrow).

 


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Fig. 1B. Focal rim of hepatic steatosis surrounding an insulinoma metastasis in 27-year-old man. Opposed-phase image (250/2.1) corresponding to A reveals rim of signal loss surrounding lesion indicating focal hepatic steatosis (arrow).

 


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Fig. 1C. Focal rim of hepatic steatosis surrounding an insulinoma metastasis in 27-year-old man. Fat-saturated opposed-phase image (250/2.1) shows that central tumor (arrow) but not surrounding rim of steatosis shows enhancement.

 


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Fig. 1D. Focal rim of hepatic steatosis surrounding an insulinoma metastasis in 27-year-old man. Intraoperative sonogram reveals same lesion as that in C with peripheral echogenic rim (arrow).

 


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Fig. 1E. Focal rim of hepatic steatosis surrounding an insulinoma metastasis in 27-year-old man. Photomicrograph of histologic specimen shows three zones: insulinoma metastasis (T), adjacent focal hepatic steatosis without tumor infiltration (asterisk), and normal hepatic parenchyma (L). (H and E, x20)

 


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Fig. 2A. Subcapsular rim of hepatic steatosis in 35-year-old woman with diabetes mellitus who had insulin in peritoneal dialysate. Unenhanced CT scan reveals irregular peripheral rim of low attenuation in liver (asterisks).

 


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Fig. 2B. Subcapsular rim of hepatic steatosis in 35-year-old woman with diabetes mellitus who had insulin in peritoneal dialysate. Axial breath-hold spoiled in-phase gradient-echo MR image (TR/TE, 250/4.2) reveals irregular peripheral subcapsular rim of higher signal intensity relative to adjacent hepatic parenchyma (arrows).

 


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Fig. 2C. Subcapsular rim of hepatic steatosis in 35-year-old woman with diabetes mellitus who had insulin in peritoneal dialysate. Opposed-phase image (250/2.1) corresponding to B shows signal loss in subcapsular rim indicating peripheral hepatic steatosis (asterisks).

 

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