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The Research Framework

Jeffrey G. Jarvik1

1 Departments of Radiology, Neurosurgery and Health Services, and the Center for Cost and Outcomes Research, University of Washington, Seattle, WA.



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Fig. 1. Diagram shows that test sensitivity focuses on first column of two-by-two table. Sensitivity equals A / (A + C), or number of patients with true-positive (TP) findings divided by all patients with positive reference test findings. + = positive test result, - = negative test result, FP = false-positive, FN = false-negative, TN = true-negative.

 


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Fig. 2. Diagram shows how test specificity focuses on second column of two-by-two table. Test specificity equals D / (B + D), or number of patients with true-negative (TN) findings divided by all patients with negative findings on reference test. + = positive test result, - = negative test result, TP = true-positive, FP = false-positive, FN = false-negative.

 


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Fig. 3. Predictive values are calculated from table rows rather than table columns. Positive predictive value equals A / (A + B), or number of true-positive (TP) findings divided by number of all patients with positive findings on index test. + = positive test result, - = negative test result, FP = false-positive, FN = false-negative, TN = true-negative.

 


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Fig. 4. Negative predictive value is calculated from second row of table and equals D / (C + D), or number of true-negative (TN) findings divided by number of all patients with negative index test results. + = positive test result, - = negative test result, TP = true-positive, FP = false-positive, FN = false-negative.

 

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