Benign Metastasizing Leiomyoma
Clinical, Imaging, and Pathologic Correlation
Simeon Abramson1,
Robert C. Gilkeson1,
Jeffrey D. Goldstein2,
Pamela K. Woodard3,
Rosana Eisenberg4 and
Neil Abramson5
1
Department of Radiology, University Hospitals of Cleveland, Case Western
Reserve University, 11100 Euclid Ave., Cleveland, OH 44106.
2
Department of Pathology, Baptist Medical Center, 800 Prudential Dr.,
Jacksonville, FL 32207.
3
Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., St. Louis, MO
63110.
4
Department of Pathology, University Hospitals of Cleveland, Case Western
Reserve University, Cleveland, OH 44106.
5
Baptist Medical Center, Baptist Regional Cancer Institute, 800 Prudential Dr.,
Jacksonville, FL 32207.
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Fig. 1A. —49-year-old asymptomatic woman with incidental discovery of
lung nodules on shoulder radiographs for trauma. Posteroanterior radiograph of
chest shows multiple bilateral nodules.
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Fig. 2A. —34-year-old asymptomatic woman. Posteroanterior chest
radiograph of left hemithorax reveals small nodules.
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Fig. 3A. —55-year-old asymptomatic woman with history of breast
carcinoma. Posteroanterior radiograph of left lung reveals two round
nodules.
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Fig. 1B. —49-year-old asymptomatic woman with incidental discovery of
lung nodules on shoulder radiographs for trauma. Axial CT scan of chest
reveals nodules ranging in diameter from 2 mm to 3.5 cm.
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Fig. 2B. —34-year-old asymptomatic woman. Axial CT scan of chest
reveals nodules better than radiograph in A.
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Fig. 3B. —55-year-old asymptomatic woman with history of breast
carcinoma. Axial CT scan of chest reveals several well-defined and smoothly
marginated nodules.
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Fig. 4. —50-year-old woman with abdominal pain. Axial CT scan of chest
reveals 3-mm well-defined nodule (arrow) in right lower lobe.
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Fig. 5A. —45-year-old woman scheduled for bladder suspension surgery.
Axial CT scan of chest reveals several lobulated nodules in right upper
lobe.
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Fig. 5B. —45-year-old woman scheduled for bladder suspension surgery.
Axial CT scan of pelvis reveals two large heterogenous masses consistent with
recurrent leiomyomata 7 years after hysterectomy for benign leiomyomata.
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Fig. 6A. —Histologic section of lung from 34-year-old woman with benign
metastasizing leiomyoma. Photomicrograph shows well-circumscribed but
unecapsulated nodule of elongated, fusiform cells arranged in interlacing
fascicles in lung. (H and E, x40)
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Fig. 6B. —Histologic section of lung from 34-year-old woman with benign
metastasizing leiomyoma. Photomicrograph of same section as A but at
higher magnification. (H and E x100). Note invagination and entrapment
of low cuboidal metaplastic bronchiolar epithelium between fascicles of smooth
muscle. When seen in cross-sectional profiles, these epithelial clefts appear
as tubules. Although cellularity is moderately dense, smooth muscle does not
show anaplasia or prominent mitotic activity.
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Copyright © 2001 by the American Roentgen Ray Society.
