Lipoatrophic—Lipodystrophic Syndromes
The Spectrum of Findings on MR Imaging
A. Premkumar1,
C. Chow1,
P. Bhandarkar1,
V. Wright1,
N. Koshy1,
S. Taylor2 and
E. Arioglu2
1
Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center,
National Institutes of Health, Bldg. 10, Rm. 1C660, 10 Center Dr. MSC 1182,
Bethesda, MD 20892-1182.
2
National Institute of Diabetes, Digestive and Kidney Diseases, National
Institutes of Health, Bldg. 10, Rm. 9S213 10, Center Dr. MSC 1829, Bethesda,
MD 20892-1829.
View larger version (72K):
[in a new window]
|
Fig. 2D. —Familial partial lipodystrophy, or Dunnigan-Kobberling
syndrome, in 26-year-old woman. Axial MR imaging section obtained through
thighs shows no subcutaneous fat and minimal intra- and intermuscular fat. Fat
in bone marrow is preserved.
|
|
View larger version (68K):
[in a new window]
|
Fig. 4E. —Acquired general lipodystrophy, or Lawrence syndrome, in
young girl. Axial T1-weighted MR image (400/9; number of exitations, 2;
matrix, 256x192) obtained through thighs shows absence of fat in
subcutaneous and intramuscular regions but preservation of fat in bone
marrow.
|
|
View larger version (118K):
[in a new window]
|
Fig. 1A. —Congenital generalized lipoatrophy in 17 year-old boy.
(Imaging parameters for A—C are TR/TE, 400/9; number of
excitations, 2; matrix, 256x192.) Axial T1-weighted MR imaging section
obtained through upper abdomen shows increased signal intensity of liver due
to fatty infiltration.
|
|
View larger version (125K):
[in a new window]
|
Fig. 1B. —Congenital generalized lipoatrophy in 17 year-old boy.
(Imaging parameters for A—C are TR/TE, 400/9; number of
excitations, 2; matrix, 256x192.) Axial MR imaging section obtained
through mid abdomen shows complete absence of subcutaneous and intraabdominal
fat.
|
|
View larger version (66K):
[in a new window]
|
Fig. 1C. —Congenital generalized lipoatrophy in 17 year-old boy.
(Imaging parameters for A—C are TR/TE, 400/9; number of
excitations, 2; matrix, 256x192.) Axial MR imaging section obtained
through mid thigh shows no subcutaneous, intramuscular, or bone marrow
fat.
|
|
View larger version (77K):
[in a new window]
|
Fig. 2A. —Familial partial lipodystrophy, or Dunnigan-Kobberling
syndrome, in 26-year-old woman. Photographs show increased adipose tissue in
patient's face and neck (A) and decreased fat in gluteal region and
lower extremities (B).
|
|
View larger version (99K):
[in a new window]
|
Fig. 2B. —Familial partial lipodystrophy, or Dunnigan-Kobberling
syndrome, in 26-year-old woman. Photographs show increased adipose tissue in
patient's face and neck (A) and decreased fat in gluteal region and
lower extremities (B).
|
|
View larger version (119K):
[in a new window]
|
Fig. 2C. —Familial partial lipodystrophy, or Dunnigan-Kobberling
syndrome, in 26-year-old woman. Axial T1-weighted MR image (TR/TE, 400/9;
number of exitations, 2; matrix, 256x192) of mid abdomen shows no
subcutaneous fat and increase in intraabdominal fat.
|
|
View larger version (110K):
[in a new window]
|
Fig. 3A. —New familial partial lipodystrophy syndrome in 30-year-old
woman. (Imaging parameters for A and B are TR/TE, 400/9; number
of exitations, 2; matrix, 256x192.) Axial T1-weighted MR image of mid
abdomen shows decrease in subcutaneous adipose tissue and relative increase in
intraabdominal adipose tissue.
|
|
View larger version (78K):
[in a new window]
|
Fig. 3B. —New familial partial lipodystrophy syndrome in 30-year-old
woman. (Imaging parameters for A and B are TR/TE, 400/9; number
of exitations, 2; matrix, 256x192.) Axial T1-weighted MR image reveals
increased subcutaneous fat in thighs.
|
|
View larger version (89K):
[in a new window]
|
Fig. 4A. —Acquired general lipodystrophy, or Lawrence syndrome, in
young girl. Photographs show patient before (A, taken at 3 years 8
months) and after (B, taken at 6 years 10 months) loss of fat that was
preceded by painful febrile panniculitis. Generalized fat loss developed in 16
weeks.
|
|
View larger version (76K):
[in a new window]
|
Fig. 4B. —Acquired general lipodystrophy, or Lawrence syndrome, in
young girl. Photographs show patient before (A, taken at 3 years 8
months) and after (B, taken at 6 years 10 months) loss of fat that was
preceded by painful febrile panniculitis. Generalized fat loss developed in 16
weeks.
|
|
View larger version (108K):
[in a new window]
|
Fig. 4C. —Acquired general lipodystrophy, or Lawrence syndrome, in
young girl. Axial T1-weighted MR imaging sections (TR/TE, 400/9; number of
exitations, 2; matrix, 256x192) obtained through abdomen reveal fatty
liver (C) and loss of subcutaneous and intraabdominal fat
(D).
|
|
View larger version (93K):
[in a new window]
|
Fig. 4D. —Acquired general lipodystrophy, or Lawrence syndrome, in
young girl. Axial T1-weighted MR imaging sections (TR/TE, 400/9; number of
exitations, 2; matrix, 256x192) obtained through abdomen reveal fatty
liver (C) and loss of subcutaneous and intraabdominal fat
(D).
|
|
View larger version (104K):
[in a new window]
|
Fig. 5A. —Acquired partial dystrophy, or Barraquer-Simons' syndrome, in
60-year-old woman. (Imaging parameters for A—C are TR/TE, 400/9;
number of exitations, 2; matrix, 256x192.) Axial T1-weighted MR imaging
section of mid abdomen reveals loss of subcutaneous fat and relative increase
in intraabdominal fat.
|
|
View larger version (97K):
[in a new window]
|
Fig. 5B. —Acquired partial dystrophy, or Barraquer-Simons' syndrome, in
60-year-old woman. (Imaging parameters for A—C are TR/TE, 400/9;
number of exitations, 2; matrix, 256x192.) Axial T1-weighted MR imaging
section through pelvis shows increased subcutaneous fat posteriorly with loss
of fat anteriorly.
|
|
View larger version (85K):
[in a new window]
|
Fig. 5C. —Acquired partial dystrophy, or Barraquer-Simons' syndrome, in
60-year-old woman. (Imaging parameters for A—C are TR/TE, 400/9;
number of exitations, 2; matrix, 256x192.) Axial T1-weighted MR imaging
section reveals increased subcutaneous fat is also present in thighs.
|
|
View larger version (124K):
[in a new window]
|
Fig. 6A. —Acquired partial lipodystrophy in 56-year-old man. (Imaging
parameters of A and B are TR/TE, 400/9; number of exitations, 2;
matrix, 256x192.) Axial T1-weighted MR imaging section obtained through
abdomen shows loss of subcutaneous fat and increased intraabdominal fat.
|
|
View larger version (67K):
[in a new window]
|
Fig. 6B. —Acquired partial lipodystrophy in 56-year-old man. (Imaging
parameters of A and B are TR/TE, 400/9; number of exitations, 2;
matrix, 256x192.) Axial T1-weighted MR imaging section obtained through
mid thigh reveals minimal subcutaneous fat and minimal (B) or no
(C) intramuscular fat.
|
|
View larger version (74K):
[in a new window]
|
Fig. 6C. —Acquired partial lipodystrophy in 56-year-old man. (Imaging
parameters of A and B are TR/TE, 400/9; number of exitations, 2;
matrix, 256x192.) Axial T1-weighted MR imaging section obtained through
mid thigh reveals minimal subcutaneous fat and minimal (B) or no
(C) intramuscular fat.
|
|
View larger version (44K):
[in a new window]
|
Fig. 7A. —Dermatomyositis-associated lipodystrophy in 19-year-old
woman. Photograph of patient with juvenile dermatomyositis-associated
lipodystrophy depicts major loss of fat in extremities.
|
|
View larger version (114K):
[in a new window]
|
Fig. 7B. —Dermatomyositis-associated lipodystrophy in 19-year-old
woman. Axial T1-weighted MR image (TR/TE, 400/9; number of exitations, 2;
matrix, 256 x 192) of abdomen shows no subcutaneous fat and increased
intraabdominal fat.
|
|
View larger version (72K):
[in a new window]
|
Fig. 7C. —Dermatomyositis-associated lipodystrophy in 19-year-old
woman. Axial T1-weighted MR imaging section (400/9; number of exitations, 2;
matrix, 256 x 192) obtained through thighs shows asymmetrical
distribution of subcutaneous fat, with more fat deposited anteromedially.
|
|
View larger version (126K):
[in a new window]
|
Fig. 8A. —Lipodystrophy of unknown origin in 57-year-old man. (Imaging
Parameters of A-C are TR/TE, 400/9; number of exitations, 2; matrix,
256 x 192.) Axial MR image shows increase in subcutaneous fat relative
to intraabdominal fat.
|
|
View larger version (101K):
[in a new window]
|
Fig. 8B. —Lipodystrophy of unknown origin in 57-year-old man. (Imaging
Parameters of A-C are TR/TE, 400/9; number of exitations, 2; matrix,
256 x 192.) Axial MR image reveals little gluteal fat and
"marbling" of gluteus muscle.
|
|
View larger version (71K):
[in a new window]
|
Fig. 8C. —Lipodystrophy of unknown origin in 57-year-old man. (Imaging
Parameters of A-C are TR/TE, 400/9; number of exitations, 2; matrix,
256 x 192.) Axial MR image reveals decrease in subcutaneous fat in
thighs, with slight asymmetry in distribution of fat.
|
|
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Copyright © 2002 by the American Roentgen Ray Society.
