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MR Imaging of Mucinous Carcinoma of the Breast

Miho Kawashima1,2, Yoshio Tamaki1, Tetsuo Nonaka1, Keiko Higuchi1, Morihiko Kimura3, Tokihiro Koida3, Yasuhiro Yanagita3 and Shiro Sugihara4

1 Department of Radiology, Gunma Cancer Center, 617-1 Takabayashi-nishi-cho, Ota-shi, Gunma 373-8550, Japan.
2 Present address: Department of Radiology, Dokkyo University School of Medicine, Koshigaya Hospital, 2-1-50, Minamikoshigaya, Koshigaya-shi, Saitama, 343-8555, Japan.
3 Department of Surgery, Gunma Cancer Center, Ota-shi, Gunma 373-8550, Japan.
4 Department of Pathology, Gunma Cancer Center, Ota-shi, Gunma 373-8550, Japan.



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Fig. 1. Graph shows time-signal intensity curve of mucinous carcinoma in seven of eight patients in our study. (Dynamic study was not performed in patient 7.) In four patients, contrast enhancement ratio after 60 sec is less than 100%, and slow contrast enhancement is observed. In three patients, curve plateaus after initial upstroke. Broken line represents time-signal intensity curve of component of solid tubular carcinoma in patient 6, and it shows wash out pattern.

 


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Fig. 2A. 66-year-old woman (patient 2) with mucinous carcinoma. T1-weighted (A) and T2-weighted (B) MR images show lobular mass with irregular border. Signal intensity in tumor is very high on T2-weighted image.

 


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Fig. 2B. 66-year-old woman (patient 2) with mucinous carcinoma. T1-weighted (A) and T2-weighted (B) MR images show lobular mass with irregular border. Signal intensity in tumor is very high on T2-weighted image.

 


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Fig. 2C. 66-year-old woman (patient 2) with mucinous carcinoma. Unenhanced MR image (C) and MR images obtained at 30 (D) and 90 (E) sec after administration of gadolinium in dynamic study show peripheral tumor enhancement at early phase and slow enhancement in tumor interior.

 


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Fig. 2D. 66-year-old woman (patient 2) with mucinous carcinoma. Unenhanced MR image (C) and MR images obtained at 30 (D) and 90 (E) sec after administration of gadolinium in dynamic study show peripheral tumor enhancement at early phase and slow enhancement in tumor interior.

 


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Fig. 2E. 66-year-old woman (patient 2) with mucinous carcinoma. Unenhanced MR image (C) and MR images obtained at 30 (D) and 90 (E) sec after administration of gadolinium in dynamic study show peripheral tumor enhancement at early phase and slow enhancement in tumor interior.

 


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Fig. 2F. 66-year-old woman (patient 2) with mucinous carcinoma. Photomicrograph of histopathologic specimen shows malignant cells floating in pools of mucin. (H and E, x150)

 


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Fig. 3A. 70-year-old woman (patient 6) with mucinous carcinoma and solid tubular carcinoma. T1-weighted (A) and T2-weighted (B) MR images show lobular mass. Low-signal lesions (solid tubular carcinoma, white arrow, B) around core of very high signal-lesions (mucinous carcinoma, black arrow, B) are seen on T2-weighted image.

 


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Fig. 3B. 70-year-old woman (patient 6) with mucinous carcinoma and solid tubular carcinoma. T1-weighted (A) and T2-weighted (B) MR images show lobular mass. Low-signal lesions (solid tubular carcinoma, white arrow, B) around core of very high signal-lesions (mucinous carcinoma, black arrow, B) are seen on T2-weighted image.

 


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Fig. 3C. 70-year-old woman (patient 6) with mucinous carcinoma and solid tubular carcinoma. Unenhanced MR image (C) and MR images obtained at 30 (D) and 90 (E) sec after administration of gadolinium in dynamic study show area of mucinous carcinoma (black arrow, C) gradually becomes bright, whereas area of solid tubular carcinoma (white arrow, C) shows early increase in density with washout.

 


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Fig. 3D. 70-year-old woman (patient 6) with mucinous carcinoma and solid tubular carcinoma. Unenhanced MR image (C) and MR images obtained at 30 (D) and 90 (E) sec after administration of gadolinium in dynamic study show area of mucinous carcinoma (black arrow, C) gradually becomes bright, whereas area of solid tubular carcinoma (white arrow, C) shows early increase in density with washout.

 


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Fig. 3E. 70-year-old woman (patient 6) with mucinous carcinoma and solid tubular carcinoma. Unenhanced MR image (C) and MR images obtained at 30 (D) and 90 (E) sec after administration of gadolinium in dynamic study show area of mucinous carcinoma (black arrow, C) gradually becomes bright, whereas area of solid tubular carcinoma (white arrow, C) shows early increase in density with washout.

 

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