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MRI of Occult Breast Carcinoma in a High-Risk Population

Elizabeth A. Morris1, Laura Liberman1, Douglas J. Ballon2, Mark Robson3, Andrea F. Abramson1, Alexandra Heerdt4 and D. David Dershaw1

1 Breast Imaging Section, Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021.
2 Medical Physics Section, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
3 Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
4 Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.



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Fig. 1. 49-year-old woman who underwent left lumpectomy 5 years earlier for infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed heterogeneously dense breasts with no suspicious findings. Sagittal contrast-enhanced T1-weighted image of left breast shows linear and ductal irregular enhancement measuring 1.7 cm (arrow) in left upper outer quadrant. MRI-guided needle localization revealed DCIS, flat type, with high nuclear grade and minimal necrosis.

 


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Fig. 2. 48-year-old woman with family history of breast cancer who underwent left upper inner quadrant lumpectomy 3 years previously for infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed heterogeneously dense breasts with postsurgical changes on left and no suspicious findings. Sagittal contrast-enhanced T1-weighted subtraction image of left breast shows clumped linear and ductal enhancement spanning 2.9 cm (arrow) in left upper inner quadrant. MRI-guided localization revealed DCIS, papillary and cribriform type.

 


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Fig. 3A. 42-year-old woman with family history of breast cancer who underwent right lumpectomy 1 year earlier for infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed extremely dense breasts with no suspicious findings. Sagittal contrast-enhanced T1-weighted image of left breast shows irregularly marginated and irregularly shaped heterogeneously enhancing 0.5-cm mass (arrow) in left upper outer quadrant.

 


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Fig. 3B. 42-year-old woman with family history of breast cancer who underwent right lumpectomy 1 year earlier for infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed extremely dense breasts with no suspicious findings. Sagittal contrast-enhanced T1-weighted delayed image of left breast shows progressive enhancement of normal parenchyma (open arrows) and washout of contrast material from mass (solid arrow). Mass was not seen on sonography.

 


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Fig. 3C. 42-year-old woman with family history of breast cancer who underwent right lumpectomy 1 year earlier for infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed extremely dense breasts with no suspicious findings. Quantitative curve shows mass has washout kinetics. MRI-guided localization and surgical excision revealed invasive ductal carcinoma, pure tubular type, measuring 0.3 cm, and DCIS. Sentinel nodes were free of tumor.

 


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Fig. 4A. 53-year-old woman with family history of breast cancer and remote history of bilateral breast reduction who had undergone right upper outer quadrant lumpectomy for infiltrating lobular carcinoma 2 years previously. Mammogram (not shown) revealed heterogeneously dense breasts with postsurgical changes and no suspicious findings. Sagittal contrast-enhanced T1-weighted image of right breast shows change resulting from prior surgery (open arrow) and spiculated, irregularly shaped, heterogeneously enhancing mass (solid arrow) in retroareolar region measuring 0.8 cm.

 


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Fig. 4B. 53-year-old woman with family history of breast cancer and remote history of bilateral breast reduction who had undergone right upper outer quadrant lumpectomy for infiltrating lobular carcinoma 2 years previously. Mammogram (not shown) revealed heterogeneously dense breasts with postsurgical changes and no suspicious findings. Sonogram of right breast shows irregular, hypoechoic, solid mass (arrow) measuring 0.5 cm and corresponding to MRI-detected lesion. Sonographically guided core biopsy yielded infiltrating ductal and infiltrating lobular carcinoma.

 

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