MRI of Occult Breast Carcinoma in a High-Risk Population
Elizabeth A. Morris1,
Laura Liberman1,
Douglas J. Ballon2,
Mark Robson3,
Andrea F. Abramson1,
Alexandra Heerdt4 and
D. David Dershaw1
1 Breast Imaging Section, Department of Radiology, Memorial Sloan-Kettering
Cancer Center, 1275 York Ave., New York, NY 10021.
2 Medical Physics Section, Department of Radiology, Memorial Sloan-Kettering
Cancer Center, New York, NY 10021.
3 Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering
Cancer Center, New York, NY 10021.
4 Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center,
New York, NY 10021.

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Fig. 1. 49-year-old woman who underwent left lumpectomy 5 years
earlier for infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS).
Mammogram (not shown) revealed heterogeneously dense breasts with no
suspicious findings. Sagittal contrast-enhanced T1-weighted image of left
breast shows linear and ductal irregular enhancement measuring 1.7 cm
(arrow) in left upper outer quadrant. MRI-guided needle localization
revealed DCIS, flat type, with high nuclear grade and minimal necrosis.
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Fig. 2. 48-year-old woman with family history of breast cancer who
underwent left upper inner quadrant lumpectomy 3 years previously for
infiltrating ductal carcinoma and ductal carcinoma in situ (DCIS). Mammogram
(not shown) revealed heterogeneously dense breasts with postsurgical changes
on left and no suspicious findings. Sagittal contrast-enhanced T1-weighted
subtraction image of left breast shows clumped linear and ductal enhancement
spanning 2.9 cm (arrow) in left upper inner quadrant. MRI-guided
localization revealed DCIS, papillary and cribriform type.
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Fig. 3A. 42-year-old woman with family history of breast cancer who
underwent right lumpectomy 1 year earlier for infiltrating ductal carcinoma
and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed extremely
dense breasts with no suspicious findings. Sagittal contrast-enhanced
T1-weighted image of left breast shows irregularly marginated and irregularly
shaped heterogeneously enhancing 0.5-cm mass (arrow) in left upper
outer quadrant.
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Fig. 3B. 42-year-old woman with family history of breast cancer who
underwent right lumpectomy 1 year earlier for infiltrating ductal carcinoma
and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed extremely
dense breasts with no suspicious findings. Sagittal contrast-enhanced
T1-weighted delayed image of left breast shows progressive enhancement of
normal parenchyma (open arrows) and washout of contrast material from
mass (solid arrow). Mass was not seen on sonography.
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Fig. 3C. 42-year-old woman with family history of breast cancer who
underwent right lumpectomy 1 year earlier for infiltrating ductal carcinoma
and ductal carcinoma in situ (DCIS). Mammogram (not shown) revealed extremely
dense breasts with no suspicious findings. Quantitative curve shows mass has
washout kinetics. MRI-guided localization and surgical excision revealed
invasive ductal carcinoma, pure tubular type, measuring 0.3 cm, and DCIS.
Sentinel nodes were free of tumor.
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Fig. 4A. 53-year-old woman with family history of breast cancer and
remote history of bilateral breast reduction who had undergone right upper
outer quadrant lumpectomy for infiltrating lobular carcinoma 2 years
previously. Mammogram (not shown) revealed heterogeneously dense breasts with
postsurgical changes and no suspicious findings. Sagittal contrast-enhanced
T1-weighted image of right breast shows change resulting from prior surgery
(open arrow) and spiculated, irregularly shaped, heterogeneously
enhancing mass (solid arrow) in retroareolar region measuring 0.8
cm.
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Fig. 4B. 53-year-old woman with family history of breast cancer and
remote history of bilateral breast reduction who had undergone right upper
outer quadrant lumpectomy for infiltrating lobular carcinoma 2 years
previously. Mammogram (not shown) revealed heterogeneously dense breasts with
postsurgical changes and no suspicious findings. Sonogram of right breast
shows irregular, hypoechoic, solid mass (arrow) measuring 0.5 cm and
corresponding to MRI-detected lesion. Sonographically guided core biopsy
yielded infiltrating ductal and infiltrating lobular carcinoma.
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Copyright © 2003 by the American Roentgen Ray Society.