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FDG PET of Rosai-Dorfman Disease of the Thymus

Ruth Lim1, Conrad Wittram1, Judith A. Ferry2 and Jo-Anne O. Shepard1

1 Department of Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114.
2 Department of Pathology, Massachusetts General Hospital, Boston, MA 02114.



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  		Fig. 1A. —43-year-old man with Rosai-Dorfman disease of thymus. Contrast-enhanced CT scan shows well-defined prevascular anterior mediastinal mass, which measures 2.5 x 1.6 cm in axial plane dimensions.

 


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  		Fig. 1B. —43-year-old man with Rosai-Dorfman disease of thymus. Axial FDG positron emission tomography image reveals focus of abnormally increased glycolytic activity corresponding in location to anterior mediastinal mass seen on CT.

 


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  		Fig. 1C. —43-year-old man with Rosai-Dorfman disease of thymus. Medium-power photomicrograph shows thymic mass consisting of proliferation of histiocytes with scattered reactive lymphoid follicles with germinal centers. (H and E, x16)

 


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  		Fig. 1D. —43-year-old man with Rosai-Dorfman disease of thymus. High-power photomicrograph reveals distinctive histiocytes of Rosai-Dorfman disease that are large with abundant finely granular pink cytoplasm and relatively large nuclei with open chromatin and distinct nucleoli. Few histiocytes show emperipolesis of lymphocytes, with intact lymphocytes (arrow) present in their cytoplasm. (H and E, x250)

 

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