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Pretransplantation Diagnosis and Staging of Hepatocellular Carcinoma in Patients with Cirrhosis: Value of Dual-Phase Helical CT

Carlos Valls1, Mònica Cos1, Juan Figueras2, Eduard Andía1, Emilio Ramos2, Anna Sánchez1, Teresa Serrano3 and Jaume Torras2

1 Institut de Diagnòstic per la Imatge, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Autovia de Castelldefels, Barcelona 08907, Spain.
2 Department of Surgery, Hospital Princeps d'Espanya, Barcelona, Spain.
3 Department of Pathology, Hospital Princeps d'Espanya, Barcelona, Spain.



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Fig. 1A. Hypervascular hepatocellular carcinoma (HCC) in 55-year-old man with chronic hepatitis C virus infection. Helical CT scan in arterial phase shows hypervascular lesion (arrow) in segment VIII of liver.

 


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Fig. 1B. Hypervascular hepatocellular carcinoma (HCC) in 55-year-old man with chronic hepatitis C virus infection. Portal phase CT scan obtained at same level as A shows that lesion (arrow) remains hyperenhancing. Moderate hyperenhancement of liver parenchyma in periphery of tumor is evident and consistent with transient hepatic attenuation difference.

 


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Fig. 1C. Hypervascular hepatocellular carcinoma (HCC) in 55-year-old man with chronic hepatitis C virus infection. Corresponding equilibrium phase image shows slight hypodensity of lesion (arrow) consistent with HCC.

 


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Fig. 1D. Hypervascular hepatocellular carcinoma (HCC) in 55-year-old man with chronic hepatitis C virus infection. Photograph of gross anatomic specimen confirms well-differentiated HCC (arrowheads).

 


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Fig. 2A. False-positive finding on helical CT in 41-year-old woman. Arterial phase CT scan shows small hyperenhancing nodule in segment V of liver (arrow).

 


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Fig. 2B. False-positive finding on helical CT in 41-year-old woman. Corresponding delayed phase CT scan shows that lesion is slightly hypoattenuating (arrow). These CT findings are highly suggestive of hepatocellular carcinoma.

 


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Fig. 2C. False-positive finding on helical CT in 41-year-old woman. Photomicrograph from histologic examination shows low-grade dysplastic nodule (arrow).

 


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Fig. 3A. Understaging of hepatocellular carcinoma on helical CT in 62-year-old man. Axial CT scan in arterial phase at level of left portal vein shows two hyperenhancing lesions in segment IV and in caudate lobe (arrowheads) consistent with hepatocellular carcinoma.

 


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Fig. 3B. Understaging of hepatocellular carcinoma on helical CT in 62-year-old man. Corresponding portal phase CT scan shows that both lesions remain hyperdense relative to liver parenchyma. Lesion in caudate lobe abuts right diaphragmatic crus and obliterates focally retrohepatic fat plane (arrows). These findings were missed preoperatively. At surgery, gross extrahepatic tumor infiltration was found and complete resection was not possible.

 

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