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Evaluation of Primary Malignancies of the Liver Using Contrast-Enhanced Sonography: Correlation With Pathology

Zhi-Hui Fan, Min-Hua Chen, Ying Dai, Yan-Bin Wang, Kun Yan, Wei Wu, Wei Yang and Shan-Shan Yin

Department of Ultrasound, School of Oncology, Peking University, 52 Fu-cheng Rd., Beijing 100036, People's Republic of China.


Figure 1
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  		Fig. 1 —Scatterplot of washout time of different groups. HCC = hepatocellular carcinoma.

 

Figure 2
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  		Fig. 2A —53-year-old man with history of hepatitis B for past 2 years. Baseline sonographic image shows focal hyperechoic lesion in right hepatic lobe (arrow).

 

Figure 3
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  		Fig. 2B —53-year-old man with history of hepatitis B for past 2 years. Arterial phase image obtained at 13 sec shows homogeneous enhancement of lesion.

 

Figure 4
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  		Fig. 2C —53-year-old man with history of hepatitis B for past 2 years. Portal venous phase image obtained at 42 sec. Lesion is hypoechoic with respect to surrounding liver.

 

Figure 5
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  		Fig. 2D —53-year-old man with history of hepatitis B for past 2 years. Lesion was confirmed as moderately to poorly differentiated hepatocellular carcinoma by biopsy histopathology with 20-gauge automatic cutting needle (H and E, x 200).

 

Figure 6
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  		Fig. 3A —41-year-old woman with history of hepatitis B for past 10 years. Baseline sonographic image shows hypoechoic lesion in right lobe (arrow).

 

Figure 7
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  		Fig. 3B —41-year-old woman with history of hepatitis B for past 10 years. Arterial phase image obtained at 13 sec shows homogeneous enhancement of lesion.

 

Figure 8
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  		Fig. 3C —41-year-old woman with history of hepatitis B for past 10 years. Late phase image obtained at 457 sec. The lesion shows washout; hypoechoic with respect to surrounding liver (arrow).

 

Figure 9
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  		Fig. 3D —41-year-old woman with history of hepatitis B for past 10 years. Pathologic diagnosis of tissue punctured from lesion with 21-gauge manual aspiration needle was well-differentiated hepatocellular carcinoma (H and E, x 200).

 

Figure 10
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  		Fig. 4A —55-year-old man with history of hepatitis B for past 20 years. Baseline sonographic image shows hypoechoic lesion with unclear border in right lobe (arrow).

 

Figure 11
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  		Fig. 4B —55-year-old man with history of hepatitis B for past 20 years. Portal venous phase image obtained at 42 sec. Lesion begins to enhance.

 

Figure 12
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  		Fig. 4C —55-year-old man with history of hepatitis B for past 20 years. Late phase image obtained at 133 sec. Lesion shows slight washout and is hypoechoic with respect to surrounding liver (arrow).

 

Figure 13
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  		Fig. 4D —55-year-old man with history of hepatitis B for past 20 years. Pathologic diagnosis of tissue punctured from lesion with 21-gauge manual aspiration needle was clear cell carcinoma (H and E, x 200).

 

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