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Fig. 8B. —Differences in sites and sizes of regions of brain activation
after memory task of patient with mild cognitive impairment and control
subject. 67-year-old man shown in B was one of group of subjects with
mild cognitive impairment who were found to have statistically less activation
than control subjects in five of seven brain regions studied; similar trend
that was not statistically significant was seen in other two brain regions.
Brain activation studies in both groups were obtained in identical fashion and
were analyzed using same statistical threshold, smoothing and clustering.
(Courtesy of Petrella J, Durham, NC) Brain activation functional imaging
performed during memory task in 67-year-old man with mild cognitive impairment
(receiving no medication) shows decreased activation (depicted in color voxel
overlay) in right frontal lobe compared with individual shown in A.
Note activation in left frontal lobe, which suggests possible contralateral
hemisphere compensatory activation.
