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Fig. 10. —Spectra from posterior cingulate cortex (point resolved
spectroscopy, TR/TE, 2,000/30; average of 128 scans) obtained from control
subject (top row), patient with mild cognitive impairment (MCI,
middle row), and patient with probable Alzheimer's disease (AD,
bottom row). Myo-inositol (MI) to creatine (Cr) ratios show
progressive increase in mild cognitive impairment (0.65) and Alzheimer's
disease (0.81) compared with control subject (0.48). Note also significant
reduction in N-acetylaspartate (NAA) to creatine (Cr) ratios in
Alzheimer's disease subject (1.33) compared with patient with mild cognitive
impairment (1.60) and control subject (1.71). CHO = choline. (Reprinted with
permission from [64])
